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KMID : 0386319840170010055
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Korean Leprosy Bulletin
1984 Volume.17 No. 1 p.55 ~ p.60
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Purine Nucleoside Phosphorylase Activities in Sera and Erythrocytes of Leprosy Patients
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金永杓/Young Pio Kim
田寅淇/崔有燮/Inn Ki Chun/Yoo Seop Choi
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Abstract
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Leprosy has two polar types. The one tuberculoid leprosy (TL) is characterized by well
preserved cellular immunity with a good prognosis and the other lepromatous leprosy
(LL) shows no cellular immunity with a poor prognosis. The present study was
designed to measure the activity of purine nucleoside phosphorylase(PNPase) in sera and
erythrocytes of leprosy patients as it's activities are known to be decreased in
cell-mediated immune deficiency diseases. The PNPase activities in sera of TL patients
((3.2±0.76)×104units/L) did not differ from those of normal subjects ((3.9
±1.03)×104units/L), but the LL Patients ((1.87±0.62)×104
units/L) showed significantly lowered activity than those of normal subjects. The
erythrocyte PNPase activities of leprosy patients, especially LL patients were
significantly lowered than those of normal subjects (Normal: 5.04±
0.16units/107cells, TL. 3.8±1.96 units/107cells, LL: 2.08±0.98
units/107cells).
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